https://data.archives-ouvertes.fr/document/inserm-00848157v1

https://data.archives-ouvertes.fr/document/inserm-00848157v1

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http://purl.org/dc/terms/title What have we learned form monogenic forms of severe insulin resistance associated with PCOS/HAIRAN?
http://purl.org/dc/terms/isPartOf https://data.archives-ouvertes.fr/revue/22715
http://purl.org/ontology/bibo/volume 71
http://purl.org/dc/terms/modified 2024-12-12T03:43:04
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http://purl.org/dc/terms/issued 2010-05
http://data.archives-ouvertes.fr/schema/meshSubject Receptor, Insulin
http://data.archives-ouvertes.fr/schema/meshSubject Polycystic Ovary Syndrome
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http://purl.org/dc/terms/bibliographicCitation Corinne Vigouroux. What have we learned form monogenic forms of severe insulin resistance associated with PCOS/HAIRAN?. Annales d'Endocrinologie = Annals of Endocrinology, 2010, 71 (3), pp.222-4. ⟨10.1016/j.ando.2010.02.017⟩. ⟨inserm-00848157⟩
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http://purl.org/ontology/bibo/doi 10.1016/j.ando.2010.02.017
http://data.archives-ouvertes.fr/schema/meshSubject Leptin
http://purl.org/dc/terms/identifier https://inserm.hal.science/inserm-00848157
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http://purl.org/dc/terms/abstract Whatever the origin of severe insulin resistance (primary insulin receptors defects or lipodystrophies), in vivo hyperinsulinemia has been clearly shown to promote ovarian growth and androgen synthesis independently of gonadotropins. In lipodystrophic syndromes, the endocrine deficiency of adipose tissue has been shown to play important pathophysiological roles in metabolic alterations. In particular leptin is decreased, contributing to the ectopic lipid storage in non-adipose cells, which inhibits insulin signalling (lipotoxicity). Finally, polycystic ovary syndrome (PCOS) features are not always present in insulin resistance syndromes with lipodystrophy. This is in favour of an aggravating, but not a primary role of post-receptor insulin resistance on ovary dysfunctions.
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http://data.archives-ouvertes.fr/schema/meshSubject Adipose Tissue
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http://purl.org/dc/terms/created 2013-07-25T15:17:02
http://data.archives-ouvertes.fr/schema/meshSubject Female
http://data.archives-ouvertes.fr/schema/meshSubject Insulin Resistance
http://data.archives-ouvertes.fr/schema/meshSubject Lipodystrophy

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https://data.archives-ouvertes.fr/document/inserm-00848157

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